33x12.5 Pro Comp Xtreme Mud Terrains with a 6.5:1 Transfer case and 5.12 Gears. Wheels great.

Highway is actually more of a problem then wheeling. And 1st gear is next to useless at crawling when in high. In low range I usually run around in 2nd unless I need to crawl, but 3rd is a bit high for steep climbs and I usually have to down shift.
The Stock SJ-410 transfer case has a 10% reduction in high and low range over the stock SJ-413 (Samurai) transfer case. So going with the 4.16 gears you won't actually see a reduction in high range. And depending on your model you won't be able to use the lower gear set in your transfer case, you will need to go to one from a Samurai. Nothing from your axles swap over to the SJ-413 other then your brakes, and your springs are 3" closer together (1.5" per side) then on a Sammy, so if you swap axles you need to re-weld all of your spring perches.
I love the fact that the SJ-410 is a bit different, but building up a Sammy would be easier. Unless you plan on replacing everything anyway, then go nuts.
