I run 5.12 axle gears, double tcases, which equates to a crawl ratio of 142:1 with 34" tires. I do run chromoly front axle shafts. The only issue I have had is I broke a rear axle when I was doing something I shouldn't have been (climbing a steep rocky hill and the rear end started bouncing).
A buddy of mine runs 5.38 axle gears, 6.5 tcase gears and 35.5" tires (Q78 swampers). He has front chromoly shafts too. He has broken one rear axle as well.
We have been wheeling for about 12 years and that is the only issues we have had axle wise.