I don't use a "Cargo Box"
I had removed my rear seat along time ago, installed a "Bunch" of 1/4" "D Rings" (Some using the rear seat latch bolt holes)
and use 1 inch ratchet straps & motorcycle "Cargo Nets" to hold all my gear from flying around on the trails.
My fear was I would survive the roll over, but get WACKED by my hydraulic jack, tool box, mini air compressor, cooler, etc.
Also it has silenced all those RATTLES from that stuff sliding around back there TO HELP;
What was "THAT NOISE?!?!?"..... Oh it must be something loose in the back there,........
500ft later that broke spring leaf lets go right into your tire sidewall !!!
Now I know that doesn't keep Thieves at bay, but until a year ago, ("Dipstick" 2/2001 - 5/27/2010) my 85# Black Lab would lay down on top of the dust cover over this gear when we went out.
My Idea for you would be a Army Surplus Metal case that I think they used for Recoil-less Rocket rounds. it is the size of a large suitcase and opens like one. The nice thing is that they are water tight.